Roller Compaction is a dry process involving compaction of materials into ribbons which are then milled to generate a granulation. This granulation is then compressed on a tablet machine. This process can be used with moisture-sensitive active pharmaceutical ingredients (API's), it improves particle size and flow, and is readily adaptable to continuous processing. Use of Avicel DG:
Avicel DG in the intra-granular phase
No extra-granular binders required.
Direct compression is the most economic process for the manufacture of tablets. Excipients are blended with the active and compressed with no need for drying. The process is suitable for use with moisture-sensitive actives but is more subject to segregation than the wet granulation approach. Avicel PH grades provide excipient solutions to many challenges of direct compression formulations including:
The earliest technology for granulating and processing drugs for tabletting, this approach enables a uniform blend and avoids segregation. The addition of Avicel® PH 101 or PH 302 in wet granulation promotes:
Super-disintegrants break a tablet into smaller fragments increasing the surface area of the dosage form and the rate of drug absorption. Ac-Di-Sol® Croscarmellose sodium is developed to:
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