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Avicel® for Solid Dose Forms

Avicel DG
Microcrystalline Cellulose, NF, Ph. Eur., JP and Anhydrous Dibasic Calcium Phosphate, USP, FCC, Ph. Eur., JP
Avicel DG is a proprietary co-spray dried MCC/DCP excipient optimized for the use in dry granulation processes. The unique characteristics of Avicel DG facilitate solid dosage form manufacturing utilizing roller compaction by improving process robustness, tablet hardness, and yields. Avicel DG offers good flow characteristics, high quality initial compactability, required for the production of robust ribbons, and excellent recompactability, resulting in enhanced tabletting performance and fewer rejected tablets. 

Avicel PH 
Microcrystalline Cellulose, NF, Ph. Eur., JP 
The introduction of Avicel PH was a catalyst for the pharmaceutical industry’s conversion to direct compression tablet technology, creating new levels of manufacturing efficiency. Today’s Avicel PH continues to set new standards, with enhanced grades designed to boost productivity and meet any formulation challenge.  

Avicel HFE
Microcrystalline Cellulose, NF, Ph. Eur., JP and mannitol, USP, Ph. Eur., JP 
Avicel HFE-102 is a new, proprietary co-spray dried MCC/mannitol excipient. The co-processing of MCC and mannitol creates a synergistic functionality, providing superior benefits versus the use of individual or dry-blended components. Avicel HFE-102 offers improvements in flow, compaction, and disintegration properties compared to traditional MCC grades. The product also exhibits less sensitivity to lubrication.  

Avicel CE 
Microcrystalline Cellulose and Guar Gum
The superior organoleptic performance of Avicel CE-15 in chewable tablets results in dramatic differences for end users, primarily in the areas of overall sensory experience and perceived taste, when compared to other tablet binders. When using Avicel CE-15, the user experiences: less grittiness, reduced tooth packing, minimal chalkiness, creamier mouthfeel, and improved overall palatability.  

Product Name Product Grades Nominal Particle Size, µm Moisture, % Loose
Bulk Density, g/cc
Roller Compaction
 
Avicel DG
45 NMT 5.0 0.25 - 0.40
Wet Granulation Avicel PH-101 50 3.0 to 5.0 0.26 - 0.31
Direct Compression

Avicel PH-102

100 3.0 to 5.0 0.28 - 0.33
Direct Compression Avicel HFE*-102 100 NMT*** 5.0 0.28 - 0.33
Superior Compactibility Avicel PH-105 20 NMT 5.0 0.20 - 0.30
Superior Flow Avicel PH-102 SCG** 150 3.0 to 5.0 0.28 - 0.34
Superior Flow Avicel PH-200 180 2.0 to 5.0 0.29 - 0.36
High Density

Avicel PH-301

50

3.0 to 5.0 0.34 - 0.45
High Density

Avicel PH-302

100

3.0 to 5.0 0.34 - 0.46
Low Moisture

Avicel PH-103

50

NMT 3 0.26 - 0.31
Low Moisture

Avicel PH-113

50

NMT 2 0.27 - 0.34
Low Moisture

Avicel PH-112

100

NMT 1.5 0.28 - 0.34
Low Moisture

Avicel PH-200 LM

180

NMT 1.5 0.30 - 0.38
Mouthfeel Improvement

Avicel CE-15

75

NMT 8 N/A
*High Functionality Excipient **Special Coarse Grade ***Not More Than

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